Topics
Topics follow the official USMLE Content Outline: each organ system is split into the categories the exam uses. Built topics are linked; the rest are on the way.
Available now
- Valvular heart disease (Cardiovascular System, 16 practice questions)
- Thyroid disorders (Endocrine System, 32 practice questions)
Human Development
- Normal age-related findings and care of the well patient coming soon
Immune System
- Disorders associated with immunodeficiency coming soon
- HIV/AIDS coming soon
- Immunologically mediated disorders coming soon
- Adverse effects of drugs on the immune system coming soon
Blood & Lymphoreticular System
- Infectious and immunologic, including microbiologic and host response to insult coming soon
- Neoplasms coming soon
- Anemia, cytopenias, and polycythemia anemias coming soon
- Coagulation disorders (hypocoagulable and hypercoagulable conditions) coming soon
- Traumatic, mechanical, and vascular disorders coming soon
- Adverse effects of drugs on the hematologic and lymphoreticular systems coming soon
Behavioral Health
- Psychotic disorders coming soon
- Anxiety disorders coming soon
- Mood disorders coming soon
- Somatic symptoms and related disorders coming soon
- Factitious disorders coming soon
- Eating disorders and impulse-control disorders coming soon
- Disorders originating in infancy/childhood coming soon
- Personality disorders coming soon
- Psychosocial disorders/behaviors coming soon
- Sexual disorders and gender dysphoria coming soon
- Substance use disorders coming soon
Nervous System & Special Senses
- Infectious, immunologic, and inflammatory disorders, including microbiologic and host response to insult coming soon
- Neoplasms (cerebral, spinal, and peripheral) coming soon
- Cerebrovascular disease coming soon
- Disorders relating to the spine, spinal cord, and spinal nerve roots coming soon
- Cranial and peripheral nerve disorders coming soon
- Neurologic pain syndromes coming soon
- Degenerative disorders/amnestic syndromes coming soon
- Global cerebral dysfunction coming soon
- Neuromuscular disorders coming soon
- Movement disorders coming soon
- Metabolic disorders coming soon
- Paroxysmal disorders coming soon
- Sleep disorders coming soon
- Traumatic and mechanical disorders and disorders of increased intracranial pressure coming soon
- Congenital disorders coming soon
- Adverse effects of drugs on the nervous system coming soon
- Disorders of the eye and eyelid coming soon
- Disorders of the ear coming soon
Skin & Subcutaneous Tissue
- Infectious, immunologic, and inflammatory disorders, including microbiologic and host response to insult coming soon
- Neoplasms coming soon
- Integumentary disorders (hair and hair follicles, nails, sweat glands, sebaceous glands, oral mucous membranes) coming soon
- Oral disease coming soon
- Disorders of pigmentation coming soon
- Traumatic and mechanical disorders coming soon
- Congenital disorders coming soon
- Adverse effects of drugs on skin and subcutaneous tissue coming soon
Musculoskeletal System
- Infectious, inflammatory, and immunologic disorders, including microbiologic and host response to insult coming soon
- Neoplasms coming soon
- Degenerative and metabolic disorders coming soon
- Traumatic and mechanical disorders coming soon
- Congenital disorders coming soon
- Adverse effects of drugs on the musculoskeletal system coming soon
Cardiovascular System 1 live
- Infectious, immunologic, and inflammatory disorders, including microbiologic and host response to insult coming soon
- Neoplasms coming soon
- Dysrhythmias coming soon
- Heart failure coming soon
- Ischemic heart disease coming soon
- Diseases of the myocardium coming soon
- Diseases of the pericardium coming soon
- Valvular heart disease 16 questions
- Hypotension coming soon
- Hypertension coming soon
- Dyslipidemia coming soon
- Vascular disorders coming soon
- Traumatic and mechanical disorders coming soon
- Congenital disorders, including disease in adults coming soon
- Adverse effects of drugs on the cardiovascular system coming soon
Respiratory System
- Infectious, immunologic, and inflammatory disorders, including microbiologic and host response to insult coming soon
- Neoplasms coming soon
- Obstructive airway disease coming soon
- Pneumoconiosis/fibrosing/restrictive pulmonary disorders/interstitial lung disease coming soon
- Respiratory failure/respiratory arrest and pulmonary vascular disorders coming soon
- Metabolic, regulatory, and structural disorders coming soon
- Disorders of the pleura, mediastinum, and chest wall coming soon
- Traumatic and mechanical disorders coming soon
- Congenital disorders coming soon
- Adverse effects of drugs on the respiratory system coming soon
Gastrointestinal System
- Infectious, immunologic, and inflammatory disorders, including microbiologic and host response to insult coming soon
- Neoplasms coming soon
- Signs, symptoms, and ill-defined disorders coming soon
- Disorders of the oral cavity, salivary glands, and esophagus coming soon
- Disorders of the stomach, small intestine, colon, rectum, anus coming soon
- Disorders of the liver and biliary system, noninfectious coming soon
- Disorders of the pancreas coming soon
- Disorders of the peritoneal cavity coming soon
- Traumatic and mechanical disorders coming soon
- Congenital disorders coming soon
- Adverse effects of drugs on the gastrointestinal system coming soon
Renal & Urinary System
- Infectious, immunologic, and inflammatory disorders, including microbiologic and host response to insult coming soon
- Neoplasms coming soon
- Abnormalities of urine/urination coming soon
- Metabolic and regulatory disorders coming soon
- Vascular disorders coming soon
- Traumatic and mechanical disorders coming soon
- Congenital disorders coming soon
- Adverse effects of drugs on the renal and urinary system coming soon
Pregnancy, Childbirth, & the Puerperium
- Prenatal care coming soon
- Obstetric complications coming soon
- Labor and delivery coming soon
- Puerperium, including complications coming soon
- Newborn (birth to 4 weeks of age) coming soon
- Adverse effects of drugs on pregnancy, childbirth, and the puerperium coming soon
- Systemic disorders affecting pregnancy, labor and delivery, and puerperium coming soon
Female and Transgender Reproductive System & Breast
- Breast coming soon
- Female reproductive system coming soon
Male and Transgender Reproductive System
- Infectious, immunologic, and inflammatory disorders, including microbiologic and host response to insult coming soon
- Neoplasms coming soon
- Metabolic and regulatory disorders, including sexual dysfunction coming soon
- Traumatic and mechanical disorders coming soon
- Congenital disorders coming soon
- Adverse effects of drugs on the male reproductive system coming soon
Endocrine System 1 live
- Diabetes mellitus and other disorders of the endocrine pancreas coming soon
- Thyroid disorders 32 questions
- Parathyroid disorders coming soon
- Adrenal disorders coming soon
- Pituitary disorders coming soon
- Hypothalamic endocrine disorders coming soon
- Multiple endocrine neoplasia (MEN1, MEN2) coming soon
- Congenital disorders coming soon
- Adverse effects of drugs on the endocrine system coming soon
Multisystem Processes & Disorders
- Infectious, immunologic, and inflammatory disorders, including microbiologic and host response to insult coming soon
- Neoplasms and related disorders coming soon
- Signs, symptoms, and ill-defined disorders coming soon
- Nutrition coming soon
- Toxins and environmental extremes coming soon
- Venomous bites and stings coming soon
- Fluid, electrolyte, and acid-base balance disorders coming soon
- Abuse coming soon
- Multiple trauma coming soon
- Shock coming soon
- Genetic, metabolic, and developmental disorders coming soon
- Adverse effects of drugs on multisystem disorders coming soon
Biostatistics, Epidemiology/Population Health, & Interpretation of the Medical Literature
- Epidemiology/population health coming soon
- Study design, types and selection of studies (includes dependent/independent variables) coming soon
- Measures of association coming soon
- Distributions of data coming soon
- Correlation and regression, uses and interpretation coming soon
- Principles of testing and screening coming soon
- Study interpretation, drawing conclusions from data coming soon
- Clinical decision making, interpretation and use of evidence-based data and recommendations coming soon
- Research ethics coming soon
Source: USMLE Step 1 Exam Content (usmle.org).
Social Sciences